India beat West Indies by 44 runs in the second one-day international on Wednesday to secure the series. Fast bowler Prasidh Krisha took four wickets.
West Indies stumbled in their pursuit for 238 in Ahmedabad, being bowled out for 193 in 46 overs. In the three-match series, India had a commanding 2-0 lead.
Suryakumar Yadav top-scored with 64 runs to help India reach 237-9 in 50 overs after being invited to bat first by West Indies, who were missing injured skipper Kieron Pollard.
The final match will take place on Friday at the same location.